Journal: ADMET & DMPK

Article Title: Antimicrobial and ADME properties of methoxylated, methylated and nitrated 2-hydroxynaphthalene-1 carboxanilides

doi: 10.5599/admet.2642

Figure Lengend Snippet: In vitro activities (MICs) of investigated compounds against mycobacteria compared to isoniazid (INH), rifampicin (RIF), and in vitro cytotoxicity assay (LC 50 ) of choice compounds on human monocytic leukemia THP-1 cells compared to oxaliplatin (OXP), camptothecin (CMP)

Article Snippet: To obtain a comprehensive overview of the antibacterial properties of the investigated compounds, all derivatives were tested in vitro against Mycobacterium tuberculosis ATCC 25177/H 37 Ra, Mycobacterium kansasii DSM 44162 and Mycobacterium smegmatis ATCC 700084; activities are expressed as MICs as reported in .

Techniques: In Vitro, Cytotoxicity Assay

Journal: Drug Design, Development and Therapy

Article Title: Investigation of Potent Anti- Mycobacterium tuberculosis Agents Derived from Pyridine Derivatives Targeting the Enoyl Acyl Carrier Protein Reductase (InhA): Design, Synthesis, and Computational Analysis

doi: 10.2147/DDDT.S566020

Figure Lengend Snippet: Evaluation of the bactericidal activity of the tested compounds through CFU analysis. The Y-axis represents % survival, the X-axis shows the control strain M. tuberculosis H37Rv cultured without compound (Rv_control), and in the presence of individual compounds indicating compound number_used concentration in μg/mL_incubation time in hours. A one-way ANOVA followed by Dunnett’s post hoc test was used to compare the untreated M. tuberculosis control strain (Rv_control) with bacterial cultures treated with the test compounds at specified concentrations and time points. The analysis revealed statistically significant differences, with adjusted *p*-values of **** <0.0001, * 0.0304, and 0.0128 for compounds 5 and 6 , respectively. All statistical evaluations and data visualizations were performed using GraphPad Prism 9 (Version 10.4.1).

Article Snippet: Minimum inhibitory concentration (MIC) evaluation against M. tuberculosis H37Rv and M. abscessus was performed using liquid 7H9/OADC medium (Middlebrook, Difco, Baltimore, MD, United States) containing different concentrations of the tested compounds.

Techniques: Activity Assay, Control, Cell Culture, Concentration Assay, Incubation

Journal: Journal of Molecular Structure

Article Title: An Insight into the Recent Developments in Anti-infective Potential of Indole and Associated Hybrids

doi: 10.1016/j.molstruc.2022.132808

Figure Lengend Snippet: Structures of indole (96-107) derivatives showing antimycobacterial activity.

Article Snippet: These novel compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis (ATCC 27294) strain.

Techniques: Activity Assay